ITC upheld a decision of 2011, which said that Samsung had violated Apple's patents in the manufacture of mobile phones, tablets and other devices.
ITC ruled that Samsung devices, affected by the decision, not sold in the U.S., but this ban is pending review as the decision by U.S. President Barack Obama.
The President has 60 days to evaluate the ITC decision, though analysts say he is unlikely to overturn the commission's decision.
"We are disappointed that the ITC issued an exclusion order based on two Apple patents," Samsung announced through a statement. "The proper focus for the smartphone industry is a global struggle in the courts, but a fair competition in the market".
Apple praised the decision, taken in the context of patent battles for global technology giant.
"With today's decision, joined ITC courts anywhere in the world, in Japan, Korea, Germany, the Netherlands and California, standing pro innovation and refusing to open Samsung copying Apple's products," the company said.
The decision is applicable to the two patents. The first is the so-called "patent Steve Jobs", named with the name of the founder of the company, which includes technology "touch-screen". The other has to do with jack audio equipment.
"This is another significant victory for Apple, - said intellectual property analyst, Florian Mueller, the BBC - especially because patents famous 'Steve Jobs' is a basic patent".
Four other violations of patents, required by Apple, was knocked out by ITC.